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KMID : 0352819920080010035
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Kosin Medical Journal
1992 Volume.8 No. 1 p.35 ~ p.46
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The Influence of Linoleic acid and Ursolic Acid on Mouse Natural Killer Cell Activity
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Abstract
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Several studies have reported that linoleic acid (LA) and ursolic acid(UA) extracted from vellow-green vegetables reveal antitumor activities. In the present study we examined the natural killer(NK) cell activity in order to elucidate the
mechanism of antitumor activity of these substances.
The findings in this study are summerized as follows. the NK cell activity was significantly augmented by LA and UA both in vitro and in vivo. The effect of LA appeared tobe proportional to its concentration, however the effect
of
UA
was inhibitory at high concentration(5.00 g/ml). Similar augmentations of NK cell activity were obtained with culture supernatants of LA or UA-exposed spleen cells and peripheral blood mononuclear cells.
With these results, we suggest that the LA or UA-exposed cells produce cytokines related to enhancement of NK cell activity.
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KEYWORD
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